N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester

Product NameN-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester
CAS2112731-94-7
MFC28H54N4O11
MW622.74856
EINECS
MOL File2112731-94-7.mol

Chemical Properties

storage temp.	Storage temp. 2-8°C
form	Viscous Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester is a branched molecule with a terminal azide group and a t-butyl ester group. Azide (N3) enables PEGylation via Click Chemistry. Boc group and the t-butyl protected carboxyl group can be deprotected under mild acidic conditions.

Uses

N-(Azido-PEG3)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Boc-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005