N-(Azido-PEG3)-N-Boc-PEG4-acid can undergo Click Chemistry with Propargyl, BCN or DBCO reagents. Boc group can be deprotected under acidic conditions. Carboxylic acid (CO2H) group is reactive with primary amino groups in the presence of EDCor HATU.
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group and is used in the synthesis of PROTACs[1] N-(Azido-PEG3)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
