Basic information Safety Related Supplier

MUCONOMYCIN A

Basic information Safety Related Supplier
MUCONOMYCIN A Basic information
MUCONOMYCIN A Chemical Properties
  • Melting point:>360° (dec)
  • alpha D23 +206° (c = 1.012 in chloroform)
  • Boiling point:512.66°C (rough estimate)
  • Density 1.1922 (rough estimate)
  • refractive index 1.5500 (estimate)
  • storage temp. −20°C
  • pka12.76±0.70(Predicted)
Safety Information
  • Hazard Codes T+
  • Risk Statements 26/27/28
  • Safety Statements 22-36/37/39-45
  • RIDADR UN 2811 6.1/PG 1
  • WGK Germany 3
  • RTECS WH1314900
  • HazardClass 6.1(a)
  • PackingGroup I
  • ToxicityLD50 in mice, rats, rabbits (mg/kg): 1.5, 0.87, 0.54 i.v. (Rüsch, Sthlin)
MSDS
MUCONOMYCIN A Usage And Synthesis
  • Uses
    Verrucarin A from Myrothecium sp has been used:
    • as a translation initiation inhibitor in P. falciparum W2 strain
    • as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
    • to test its cytotoxicity in renal cell carcinoma cells

  • DefinitionChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.
  • General Description
    Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.
  • Biochem/physiol ActionsVerrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells
MUCONOMYCIN A(3148-09-2)Related Product Information
MUCONOMYCIN ASupplierMore
  • Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
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  • Company Name:Sigma-Aldrich
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  • Email:orderCN@merckgroup.com;orderCN@merckgroup.com
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  • Tel:15801484223 010-60605840-
  • Email:psaitong@jm-bio.com
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  • Tel:meitaochem@126.com
  • Email:meitaochem@126.com
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  • Tel:16314854226
  • Email:inquiry@bocsci.com
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