Uses
Verrucarin A from
Myrothecium sp has been used:
- as a translation initiation inhibitor in P. falciparum W2 strain
- as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
- to test its cytotoxicity in renal cell carcinoma cells
Definition
ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.
General Description
Verrucarin derived from the
Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.
Biochem/physiol Actions
Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells
