3-Acetyl-5-bromopyridine

75-16-1

183608-47-1

38940-62-4

To a solution of 5-bromo-N-methoxy-N-methylnicotinamide (2.08 g, 8.5 mmol) in tetrahydrofuran (THF, 20 mL) was slowly added methylmagnesium bromide (MeMgBr, 1.52 g, 12.75 mmol) at -78 °C. The reaction mixture was stirred at room temperature for 2 h before the reaction was quenched with deionized water. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure and the resulting residue was purified by fast column chromatography to afford the target product 3-acetyl-5-bromopyridine (1.5 g, 88% yield).