抑二肽素A
中文名称:抑二肽素A
英文名称:DIPROTIN A
CAS号:90614-48-5
分子式:C17H31N3O4
分子量:341.45
EINECS号:
Mol文件:90614-48-5.mol
抑二肽素A 性质
| 沸点 | 583.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.140±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO:250.0(最大浓度 mg/mL);732.17(最大浓度 mM) 水:67.08(最大浓度 mg/mL);196.44(最大浓度 mM) |
| 酸度系数(pKa) | 3.72±0.22(Predicted) |
| 形态 | 白色至类白色固体。 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble in water at 1mg/ml |
| InChI | 1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24) |
| InChIKey | JNTMAZFVYNDPLB-UHFFFAOYSA-N |
| SMILES | CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O |
| CAS 数据库 | 90614-48-5(CAS DataBase Reference) |
抑二肽素A 用途与合成方法
Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
IC50: DPP-IV
Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.
Western Blot Analysis
| Cell Line: | Human endothelial cells [1] |
| Concentration: | 100 μM |
| Incubation Time: | 30 minutes after CXCR4-blocker or Src-inhibitor treatment |
| Result: | Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs. |
Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
| Animal Model: | Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice |
| Dosage: | 70 μg/kg |
| Administration: | Intraperitoneal injection; twice daily; 7 days |
| Result: | Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. |
抑二肽素A 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-111174R | 抑二肽素A | 90614-48-5 | 5 mg | 1500 |
| 2026-09-15 | HY-111174R | 抑二肽素A | 90614-48-5 | 10 mg | 2250 |
抑二肽素A供应商 更多
北京百灵威科技有限公司
联系电话：18210857532 18210857532
产品介绍：
英文名称：Diprotin A
CAS：90614-48-5
包装信息：50Mg,5Mg
备注：化学试剂、精细化学品、医药中间体、材料中间体
吉尔生化(上海)有限公司
联系电话：21-61263452 13641803416
产品介绍：
英文名称：Diprotin A
CAS：90614-48-5
纯度：95% HPLC,98% HPLC
包装信息：10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
大连美仑生物技术有限公司
联系电话：0411-62910999 13889544652
产品介绍：
英文名称：Diprotin A(Ile-Pro-Ile)
CAS：90614-48-5
纯度：>98%,BR
包装信息：5MG;25MG;
备注：MB5600
