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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Basic information
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties
  • Melting point:229-229.5 °C
  • alpha D23 +6.6° (c = 4.2 in 1:1 chloroform-methanol)
  • storage temp. −20°C
  • Merck 14,2477
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • InChIKeyKILNVBDSWZSGLL-KXQOOQHDSA-N
  • CAS DataBase Reference63-89-8(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 3
  • 10-21
  • HS Code 29232000
MSDS
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Usage And Synthesis
  • Chemical Propertieswhite powder
  • Uses1,2-dipalmitoyl-sn-glycero-3-phosphocholine is a major phospholipid constituent and primary surface tension lowering component of natural lung surfactant. Colfosceril Palmitate is used as pulmonary surfactant and diagnostic aid (fetal lung maturity).
  • DefinitionChEBI: A phosphatidylcholine 32:0 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl). A synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of pulmonary surfactants.
  • Purification MethodsIt has three crystalline forms 1, 2 and ' which change at 60-70o and at 229o, respectively. In order to obtain a fine powder, ~2 g are dissolved in CHCl3 (15mL) and pet ether (b 35-60o) is added; the solution is evaporated to dryness in vacuo at <20o and then dried at 0.1mm over CaCl2. [Baer & Maurukas J Am Chem Soc 74 158 1952, Baer & Kates J Biol Chem 185 615 1950, Beilstein 4 IV 1463.]
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE(63-89-8)Related Product Information
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