ChemicalBook Product Catalog Chemical Reagents Organic reagents Phenols 2-Amino-4-chlorophenol

2-Amino-4-chlorophenol

Product Name2-Amino-4-chlorophenol
CAS95-85-2
MFC6H6ClNO
MW143.57
EINECS202-458-9
MOL File95-85-2.mol

Chemical Properties

Melting point	136-141 °C(lit.)
Boiling point	185.5°C (rough estimate)
Density	1.2028 (rough estimate)
refractive index	1.5618 (estimate)
storage temp.	2-8°C
solubility	2.3g/l
form	Solid
pka	9.31±0.18(Predicted)
Colour Index	76525
color	Pale Orange to Light Brown
Water Solubility	Insoluble. <0.1 g/100 mL at 20 ºC
BRN	774859
Stability	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	2-Amino-4-chlorophenol (95-85-2)
InChI	1S/C6H6ClNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2
InChIKey	SWFNPENEBHAHEB-UHFFFAOYSA-N
SMILES	Nc1cc(Cl)ccc1O
CAS DataBase Reference	95-85-2(CAS DataBase Reference)
IARC	2B (Vol. 123) 2020
NIST Chemistry Reference	5-Chloro-2-hydroxyaniline(95-85-2)
EPA Substance Registry System	2-Amino-4-chlorophenol (95-85-2)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38-20/21/22
Safety Statements	26-36-36/37/39
RIDADR	UN 2673
WGK Germany	3
RTECS	SJ5700000
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	II
HS Code	29222900
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 4 Oral Carc. 2

MSDS

Provider	Language
5-Chloro-2-hydroxyaniline	English
SigmaAldrich	English
ACROS	English
ALFA	English

Usage And Synthesis

Chemical Properties

2-Amino-4-chlorophenol is a grayish to light brown crystalline solid or powder

Uses

2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis.

Uses

Intermediate.

General Description

5-Chloro-2-hydroxyaniline is a light brown colored crystalline solid. 5-Chloro-2-hydroxyaniline may be toxic by ingestion. 5-Chloro-2-hydroxyaniline is insoluble in water. 5-Chloro-2-hydroxyaniline is used to make other chemicals.

Air & Water Reactions

5-Chloro-2-hydroxyaniline may be sensitive to prolonged exposure to air and/or light. Insoluble in water.

Reactivity Profile

5-Chloro-2-hydroxyaniline may react with strong oxidizing agents.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Safety Profile

A poison. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also AROMATIC MINES and CHLORIDES.

Potential Exposure

Used as a chemical raw material, especially in dye manufacture

Shipping

UN2673 2-Amino-4-chlorophenol, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron, moisture and temperatures .43 C.

2-Amino-4-chlorophenol

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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