ZT-12-037-01

Product NameZT-12-037-01
CAS2328073-61-4
MFC21H31N5O2
MW385.5
EINECS
MOL File2328073-61-4.mol

Chemical Properties

storage temp.	2-8°C(protect from light)
solubility	DMSO: 8.33 mg/mL (21.61 mM)
form	Solid
color	White to off-white

Usage And Synthesis

Biological Activity

ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.

in vitro

Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.

in vivo

ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.

target

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Target	Value
STK19 (Cell-free assay)	23.96 nM
STK19 (D89N) (Cell-free assay)	27.94 nM