ZT-12-037-01
- Product NameZT-12-037-01
- CAS2328073-61-4
- CBNumberCB54927142
- MFC21H31N5O2
- MW385.5
- MDL NumberMFCD32197197
- MOL File2328073-61-4.mol
Chemical Properties
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: 8.33 mg/mL (21.61 mM) |
| form | Solid |
| color | White to off-white |
ZT-12-037-01 Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0090099 | 5mg | $80 | ZT-12-037-01 98.21% |
Buy |
| ChemScene CS-0090099 | 10mg | $140 | ZT-12-037-01 98.21% |
Buy |
| Axon Medchem Axon2937 | 25mg | $335.5 | ZT-12-037-01 99% |
Buy |
| ChemScene CS-0090099 | 50mg | $560 | ZT-12-037-01 98.21% |
Buy |
| ChemScene CS-0090099 | 100mg | $980 | ZT-12-037-01 98.21% |
Buy |
ZT-12-037-01 Chemical Properties,Usage,Production
Biological Activity
ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.in vitro
Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.
in vivo
ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.
target
