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Trichlormethiazide

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Trichlormethiazide Basic information
Trichlormethiazide Chemical Properties
  • Melting point:248-250℃
  • Boiling point:631.3±65.0 °C(Predicted)
  • Density 1.748
  • refractive index 1.6000 (estimate)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • pkapKa 6.9(acetone/H2O) (Uncertain)
  • Merck 14,9624
  • CAS DataBase Reference133-67-5(CAS DataBase Reference)
  • EPA Substance Registry SystemTrichlormethiazide (133-67-5)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 42/43
  • Safety Statements 36
  • WGK Germany 2
  • RTECS DK8925000
  • HS Code 2935904000
  • Hazardous Substances Data133-67-5(Hazardous Substances Data)
  • ToxicityLD50 orally in rats: >20000 mg/kg (Goldenthal)
MSDS
Trichlormethiazide Usage And Synthesis
  • Chemical PropertiesTrichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.
  • OriginatorNaqua,Schering,US,1960
  • Usesdiuretic, antihypertensive
  • UsesTrichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
    Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).
  • Manufacturing ProcessA mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.
  • Therapeutic FunctionDiuretic
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