ChemicalBook > CAS DataBase List > Trichlormethiazide

Trichlormethiazide

Trichlormethiazide Structure
Trichlormethiazide
  • CAS No.133-67-5
  • Chemical Name:Trichlormethiazide
  • CBNumber:CB5407444
  • Molecular Formula:C8H8Cl3N3O4S2
  • Formula Weight:380.66
  • MOL File:133-67-5.mol
Trichlormethiazide Property
  • Melting point: :248-250℃
  • Boiling point: :631.3±65.0 °C(Predicted)
  • Density  :1.748
  • refractive index  :1.6000 (estimate)
  • storage temp.  :Keep in dark place,Inert atmosphere,Room temperature
  • pka :pKa 6.9(acetone/H2O) (Uncertain)
  • Merck  :14,9624
  • CAS DataBase Reference :133-67-5(CAS DataBase Reference)
  • FDA UNII :Q58C92TUN0
  • ATC code :C03AA06
  • EPA Substance Registry System :Trichlormethiazide (133-67-5)
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :42/43
  • Safety Statements  :36
  • WGK Germany  :2
  • RTECS  :DK8925000
  • HS Code  :2935904000
  • Hazardous Substances Data :133-67-5(Hazardous Substances Data)
  • Toxicity :LD50 orally in rats: >20000 mg/kg (Goldenthal)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H317-H334
  • Precautionary statements P261-P280-P284-P304+P340-P342+P311
Trichlormethiazide Price More Price(16)
  • Brand: Sigma-Aldrich
  • Product number: T1016
  • Product name : Trichlormethiazide
  • Purity: ≥98%
  • Packaging: 1g
  • Price: $48.5
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1681000
  • Product name : Trichlormethiazide
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $350
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: T1318
  • Product name : Trichloromethiazide
  • Purity: >99.0%(T)
  • Packaging: 10g
  • Price: $157
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 29331
  • Product name : Trichlormethiazide
  • Purity: 
  • Packaging: 1g
  • Price: $25
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 29331
  • Product name : Trichlormethiazide
  • Purity: 
  • Packaging: 5g
  • Price: $88
  • Updated: 2021/12/16
  • Buy: Buy

Trichlormethiazide Chemical Properties,Usage,Production

  • Chemical Properties Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.
  • Originator Naqua,Schering,US,1960
  • Uses diuretic, antihypertensive
  • Uses Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
  • Uses Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
    Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).
  • Manufacturing Process A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.
  • Therapeutic Function Diuretic
Trichlormethiazide Preparation Products And Raw materials
Raw materials
Preparation Products
Global(146)Suppliers
  • Supplier:
    Hangzhou FandaChem Co.,Ltd.
  • Tel:008615858145714
  • Fax:+86-571-56059825
  • Email:fandachem@gmail.com
  • Country:China
  • ProdList:9156
  • Advantage:55
  • Supplier:
    ATK CHEMICAL COMPANY LIMITED
  • Tel:+86 21 5161 9050/ 5187 7795
  • Fax:+86 21 5161 9052/ 5187 7796
  • Email:ivan@atkchemical.com
  • Country:CHINA
  • ProdList:26782
  • Advantage:60
  • Supplier:
    career henan chemical co
  • Tel:+86-0371-55982848
  • Fax:
  • Email:sales@coreychem.com
  • Country:China
  • ProdList:29953
  • Advantage:58
133-67-5, TrichlormethiazideRelated Search:
  • 6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
  • 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid
  • 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide
  • 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1
  • 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
  • Achletin
  • Anistadin
  • Aponorin
  • Carvacron
  • Chlopolidine
  • Ciba 7057-Su
  • ciba7057-su
  • component of Metatensin
  • component of Naquival
  • Cretonin
  • Diu-Hydrin
  • Diurazida
  • Diurese
  • Diuroral
  • Trichlormethiazid
  • Trichloromethiadiazide
  • Triclordiuride
  • Triclormetiazide
  • Triflumen
  • 3-Dichlormethylhydrochlorothiazide
  • TRICHLORMETHIAZIDE,USP
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide (6CI, 8CI, 9CI)
  • 6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • NSC 61560
  • Salirom
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (-)- (9CI)
  • Natril
  • Navis
  • Nydor
  • Pluvex
  • 6-chloro-3-(dichloromethyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • Trichlormethiazide (200 mg)
  • TRICLORMETIAZIDA
  • trichlormethtazide
  • TRICHLORMETHIAZIDE
  • TRICHLOROMETHIAZIDE
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
  • 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr
  • 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1
  • 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d
  • 3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
  • 3-dichloromethylhydrochlorothiazide
  • 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam
  • e1,1-dioxide
  • Esmarin
  • Eurinol
  • Fluitran
  • Flurese