Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD50 in mice of 93 mg/kg[1].Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over[3].
| Animal Model: | Wistar rats[3] |
| Dosage: | 4, 10, 25, 63 mg/kg and 100 mg/kg |
| Administration: | Intravenous injection; 30 days |
| Result: | Led to death of rat at 100 mg/kg. |
