沙加霉素
沙加霉素 性质
| 熔点 | >205°C (dec.) |
|---|---|
| 沸点 | 667℃ |
| RTECS号 | WK2196000 |
| 闪点 | >110°(230°F) |
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | 可溶于DMSO（非常轻微、加热、超声处理）、水（轻微） |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
| 水溶解性 | Freely soluble in water |
| 稳定性 | 吸湿性 |
沙加霉素 用途与合成方法
MIC: 0.001-8.3 μg/ml ( Pseudomonas , Proteus , Klebsiella pneumoniae , Serratia )
Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).
Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD 50 in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.
| Animal Model: | Wistar rats |
| Dosage: | 4, 10, 25, 63 mg/kg and 100 mg/kg |
| Administration: | Intravenous injection; 30 days |
| Result: | Led to death of rat at 100 mg/kg. |
沙加霉素 化学药品说明书
沙加霉素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-108307 | 沙加霉素 | 66803-19-8 | 50mg | 520 |
| 2024-01-25 | HY-108307 | 沙加霉素 | 66803-19-8 | 100mg | 680 |
