离子霉素 性质
| 沸点 | 817.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.072±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 在乙醇中水中的溶解度为至10mM，在DMSO中水中的溶解度为至10mM。 |
| 形态 | 蜡状固体 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 颜色 | 粘黄色 |
| BRN | 3642126 |
| 稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达3个月。 |
离子霉素 用途与合成方法
Calcium ionophore
Ionomycin is a Calcium ionophore and an antibiotic produced by
Streptomyces conglobatus
.
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca
2+
concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 22-36/37/38 |
| 安全说明 | 36-36/37/39-27-26-24/25 |
| WGK Germany | 3 |
| RTECS号 | NO0650000 |
| F | 8-10 |
| 危险等级 | 3 |
| 海关编码 | 29419090 |
离子霉素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-13434 | 离子霉素 | 56092-81-0 | 1mg(14.1mM * 100μL in Ethanol) | 1450 |
| 2024-01-25 | HY-13434 | 离子霉素 | 56092-81-0 | 5mg(14.1mM * 500μL in Ethanol) | 3900 |
