Prednicarbate

Prednicarbate is a potent topical antiinflammatory agent with minimal systemic effects. It is useful in the treatment of cutaneous inflammatory disorders such as eczema and psoriasis.

Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone . It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice. Formulations containing prednicarbate have been used to treat chronic hand eczema.

White or almost white, crystalline powder.

Hoechst AG (W. Germany)

Topical anti-inflammatory agent. Glucocorticoid.
Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.

ChEBI: Prednicarbate is a corticosteroid hormone.

Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.

Dermatop (Sanofi Aventis).

Prednicarbate, 17-[(ethoxycarbonyl)oxy]-11β-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, is a prednisolone derivative with a C21 propionateester and a C17 ethyl carbonate group. It is availablefor use only in a 0.1% topical cream. Prednicarbate is amedium-potency GC.

[1] H G ALPERMANN  H G V  J Sandow. [Animal experiment studies on the topical and systemic effectiveness of prednisolone-17-ethylcarbonate-21-propionate].[J]. Zeitschrift fur Hautkrankheiten, 1986, 61 Suppl 1: 7-17.
[2] NICHOLAS S. BODOR  Laszlo B  Susan Tatar Kiss Buns. Novel soft steroids: effects on cell growth in vitro and on wound healing in the mouse[J]. Steroids, 1991, 56 8: Pages 434-439. DOI: 10.1016/0039-128x(91)90032-q
[3] STEPHANIE SOOST. Topical therapy of hand eczema – analysis of the prescription profile from dermatologists in private practice[J]. Journal Der Deutschen Dermatologischen Gesellschaft, 2011, 10 3: 180-184. DOI: 10.1111/j.1610-0387.2011.07787.x