Research has found that, under transition metal-free conditions, a series of 4-Aminoguinoline and their derivatives can be synthesized via a three-component one-pot method using amines, benzenesulfonyl acetonitrile, and dimethyl sulfoxide as substrates through catalytic oxidation cyclization reactions.
Light brown to grey solid
4-Quinolinamine and its derivatives are commonly used as anti-malarial drugs and also have potential therapeutic effects on patients afflicted with arthritis (and/or related diseases).
It has been purified by zone refining and recrystallisation from *C6H6, EtOH or H2O. The hydrochloride has m 308o (from MeOH), and the picrate has m 277o (from EtOH). [Albert et al. J Chem Soc 2240 1948, Beilstein 22 III/IV 4611, 22/10 V 341.]
