SPhos Pd G2

Product NameSPhos Pd G2
CAS1375325-64-6
MFC38H45ClNO2PPd
MW720.63
EINECS
MOL File1375325-64-6.mol

Chemical Properties

Melting point	218°C (dec.)
storage temp.	2-8°C, protect from light, stored under nitrogen
form	Powder
color	white
InChIKey	PYMQIHHZINPLDV-UHFFFAOYSA-N
SMILES	P(C1CCCCC1)(C1CCCCC1)(C1C=CC=CC=1C1C(=CC=CC=1OC)OC)[Pd+2]1(NC2=CC=CC=C2C2=CC=CC=[C-]12)[Cl-]

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

Usage And Synthesis

Reactions

Palladium precatalyst for Suzuki-Miyaura coupling reactions. Reactions of 1375325-64-6

Uses

Application in Suzuki-Miyaura coupling:

Self-arylation of 1-alkyl-3-bromo-2-phenyl-2,1-borazaronaphthalenes to form 2,1-borazaronaphthols.
Suzuki–Miyaura coupling of [Ru(bpy)₂]⁺ with 4-carboxyphenylboronic acid.
Suzuki–Miyaura coupling of β-borylated porphyrins with 2-iodoaniline.

General Description

SPhos Pd G2 is a second generation (G2) precatalyst in which phenethylamine based backbone of the (G1) complex is substituted with a biphenyl-based ligand. This improvement on the previous generation allows creating the active palladium species at room temperature with weak phosphate or carbonate bases. The catalyst proves remarkably adept at achieving a variety of Suzuki-Miyaura couplings among other cross-coupling reactions.

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings