Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

1. Useful catalyst for the Suzuki Cross-Coupling of dioxolanylethyltrifluorborate and aryl/heteroaryl chlorides.
2. Useful catalyst for the Suzuki Cross-Coupling of benzyloxyethyltrifluoroborate.

Yellow powder

Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium is useful catalyst for the Suzuki Cross-Coupling of dioxolanylethyltrifluorborate and aryl/heteroaryl chlorides.

Dichlorobis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II) is a highly active, air-stable catalyst for Suzuki-Miyaura cross-coupling with aryl halides including 5- and 6-membered heteroaryl chlorides.

To a 500 mL reaction was added 10 g (1,5-cyclooctadiene) palladium dichloride, the reaction flask was replaced with a nitrogen atmosphere,19.6 g of di-tert-butyl-4-dimethylaminophenylphosphine and 200 mL of anhydrous tetrahydrofuran were added. The mixture was stirred at room temperature for 16 hours; There was a solid precipitation; filtration and drying gave a pale yellow powder product bis (di-tert-butyl-4-dimethylaminophenylphosphine) palladium chloride. The yield was 97 percent.