SR1001
SR1001 性质
| 密度 | 1.640±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 二甲基亚砜：>5mg/mL |
| 酸度系数(pKa) | 5.90±0.50(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 可在-20°下的DMSO中的溶液保存长达3个月。 |
| InChI | 1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25) |
| InChIKey | OZBSSKGBKHOLGA-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1nc(C)c(s1)S(=O)(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F |
SR1001 用途与合成方法
| Target | Value |
|
RORγ
() | 111 nM(Ki) |
|
RORα
() | 172 nM(Ki) |
SR1001 inhibits the development of murine T H 17 cells by inhibition of IL-17A gene expression and protein production. SR1001 reduces the interaction of a coactivator TRAP220 NR box 2 peptide with ROR γ in a dose dependent manner (IC 50 value≈117 nM). Additionally, SR1001 inhibits the expression of cytokines when added to differentiated murine or human T H 17 cells.
SR1001 effectively suppresses the clinical severity of autoimmune disease in mice. Administration of SR1001 to C57BL/6 mice suppresses the expression of hepatic ROR target genes, Cyp7b1, Rev-erbα, and Serpine 1. SR1001 a ROR α inverse agonist eliminats the circadian pattern of expression of citrate synthase mRNA in mice.
SR1001 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-07-06 | S6724 | SR1001 | 1335106-03-0 | 5mg | 797.75 |
| 2026-07-06 | S6724 | SR1001 | 1335106-03-0 | 25mg | 3527.83 |
