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Modafinil

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Modafinil Basic information
Modafinil Chemical Properties
  • Melting point:164-166°C
  • Boiling point:559.1±50.0 °C(Predicted)
  • Density 1.283±0.06 g/cm3(Predicted)
  • Flash point:2℃
  • storage temp. Store at +4°C
  • solubility DMSO: 18 mg/mL, soluble
  • pka14.88±0.40(Predicted)
  • form white solid
  • color white
  • CAS DataBase Reference68693-11-8(CAS DataBase Reference)
Safety Information
MSDS
Modafinil Usage And Synthesis
  • DescriptionMarketed as a wakefulness promoting agent, modafinil belongs to the group of medicines known as central nervous system (CNS) stimulants, which is commonly used to promote wakefulness and reduce excessive daytime sleepiness in patients with narcolepsy, obstructive sleep apnea, hypopnea syndrome, shift-work sleep disorder or circadian rhythm sleep disorder. Besides, recently studies have showed that modafinil may be effective to help cocaine addicts fight against their addiction.
    The sleepiness-preventing effects of modafinil functions by stimulating certain parts of the brain, in which the neurons are activated by modafinil. It binds to the dopamine reuptake pump so as to inhibit the reuptake of dopamine from the cell, while the extracellular dopamine increases, thus preventing drowsiness and keeping people from falling asleep.
  • Referenceshttps://en.wikipedia.org/wiki/Modafinil
    http://bodyandhealth.canada.com/drug/getdrug/apo-modafinil
    https://www.drugbank.ca/drugs/DB00745
  • DescriptionModafinil, a centrally active α1-adrenergic agonist, was marketed in France as a psychostimulant for the treatment of narcolepsy and idiopathic hypersomnia including Gelineau's syndrome. In monkeys, modafinil was found to induce potent behavioral stimulation and awakening without stereotyped behavior. In narcoleptic patients, modafinil reduces the daily number of sleep attacks significantly and markedly improves performance. The mechanism of action for its locomotor effects was reported to be due to the stimulation of the central α1-adrenergic system, opposite to amphetamine and methylphenidate, which act mainly by dopaminergic mechanisms. Modafinil has been reported to exhibit minimal peripheral side effects at therapeutic doses and appears to have low abuse potential. The use of modafinil in the treatment of cerebral infarction and ischemia has been claimed.
  • Chemical PropertiesCrystalline Solid
  • OriginatorLafon (France)
  • UsesA central nervous system vigilance promoting agent. Possesses neuroprotective properties. This is a controlled substance (stimulant)
  • UsesACE inhibitor, antihypertensive
  • UsesModafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.
  • brand nameProvigil (Cephalon);Modiodal.
  • General DescriptionModafinil (Provigil) has overall wakefulness-promotingproperties similar to those of central sympathomimetics. It isconsidered an atypical α1-norepinephrine (NE) receptorstimulant and is used to treat daytime sleepiness in narcolepsypatients. Adverse reactions at therapeutic doses arereportedly not severe and may include nervousness, anxiety,and insomnia. Modafinil is used by oral administration.
  • Biological ActivityPsychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
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