甲磺酸奈非那韦
甲磺酸奈非那韦 性质
| 熔点 | 131-135°C |
|---|---|
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | 二甲基亚砜：≥2mg/mL |
| 酸度系数(pKa) | pKa -1.20(at 25℃) |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | 4.5g/L(temperature not stated) |
| Merck | 14,6443 |
| BCS Class | 2,4 |
| 稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
| InChIKey | NQHXCOAXSHGTIA-SKXNDZRYSA-N |
| CAS 数据库 | 159989-65-8(CAS DataBase Reference) |
甲磺酸奈非那韦 用途与合成方法
| Target | Value |
|
HIV protease
(Cell-free assay) | 2 nM(Ki) |
Nelfinavir (AG1341) Mesylate (1-10 μM; 48 hours) inhibits the proliferation of multiple myeloma cells.
Nelfinavir Mesylate inhibits 26S chymotrypsin-like proteasome activity, impairs proliferation and triggers apoptosis of the myeloma cell lines and fresh plasma cells.
Nelfinavir Mesylate (1-10 μM; 17 hours) induces apoptosis of multiple myeloma cell lines.
Nelfinavir Mesylate (5 μM; 0-24 hours) decreases the phosphorylation of AKT.
Nelfinavir Mesylate activates the cleavage of caspase-3, decreases the phosphorylation of AKT, STAT-3, ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system.
Cell Proliferation Assay
| Cell Line: | RPMI, LP1, U266, OPM2 and MM1S cells |
| Concentration: | 1, 2, 5, 10 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the proliferation of RPMI, LP1, U266, OPM2 and MM1S cell lines in a dose-dependent manner with an IC 50 of 1-5 μM. |
Apoptosis Analysis
| Cell Line: | LP1 and U266 cells |
| Concentration: | 1-10 μM |
| Incubation Time: | 17 hours |
| Result: | Induced a dose-dependent increase in the percentage of annexin V + /propidium iodide + cells. |
Western Blot Analysis
| Cell Line: | U266 cells |
| Concentration: | 5 μM |
| Incubation Time: | 0-24 hours |
| Result: | The level of AKT phosphorylation in U266 cells decreased. |
甲磺酸奈非那韦 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | 46620 | 甲磺酸奈非那韦 | 159989-65-8 | 250mg | 4009 |
| 2024-11-08 | 46620 | 甲磺酸奈非那韦 | 159989-65-8 | 1g | 13877 |
