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6-Acetamidohexanoic acid

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6-Acetamidohexanoic acid Basic information
6-Acetamidohexanoic acid Chemical Properties
  • Melting point:102-104 °C(lit.)
  • Boiling point:303.86°C (rough estimate)
  • Density 1.1599 (rough estimate)
  • refractive index 1.4590 (estimate)
  • storage temp. Sealed in dry,Room Temperature
  • pka4.75±0.10(Predicted)
  • Merck 14,45
  • CAS DataBase Reference57-08-9(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 3
  • HS Code 29241900
MSDS
6-Acetamidohexanoic acid Usage And Synthesis
  • Chemical PropertiesWHITE POWDER
  • OriginatorAcexamic acid ,Flamma
  • Uses6-Acetamidohexanoic acid is used after oral administration of an antiulcer agent, zinc acexamate (ZAC) for treatment of gastric ulcer or small bowel inflammation.
  • Useswound healing agent
  • Manufacturing Process400 L of demineralized water, 5.0 kg of calcium hydroxide, and 155.0 kg (1000 moles) of acetyl-caprolactame are introduced under stirring and at a temperature of about 25°C into a 1000 L stainless double walled reactor.
    The temperature is raised to 30°C. 75.0 kg of calcium hydroxide are introduced stepwise in the form of successive amounts of 2.0 kg each in the medium, under stirring and at a temperature adjusted and maintained 25°- 30°C through external cooling, in a manner such that the time required to introduce into the reactor the whole amount of calcium hydroxide approximates 1.5 h. When the stirring is stopped, the pH is about 7.5-7.8.
    The obtained mixture is stirred continuously at a temperature of 30°C during 14 h. At the end of this operation the pH is again adjusted at a value 7.5-7.8.
    The hydrolysate is filtered on a 60 x 60 pressfilter comprising 6 compartments and equipped with fabrics of the polyester known under the designation TERGAL which have been previously coated with a suspension of a cellulose commercialized under the trademark SOLKA FLOX BW20. The duration of filtration is of 1.5 h. 580 L of the filtrate are recovered and subjected to a concentration under reduced pressure in an evaporator the volume of which is of 750 L, at a distillation temperature ranging from 45°-50°C under a reduced pressure of 10-15 Torr.
    The operation is ran until concentration of the solution to 280 L, the concentrated solution being then left standing. The crystallisation is already considerable 2 h after the end of the operation of concentration. Crystallisation is ended after 16-24 h.
    The crystals are centrifuged at a speed of 700 revolutions/minute. The centrifuged crystals of calcium acexamate are washed twice on the centrifuge with 20 l of acetone. 107.0 kg of crystals are obtained, which are dried under vacuum at 40°C. The 96.0 kg of dry calcium acexamate obtained are ground and sifted.
    Acexamic acid may be produced by treatment of the calcium acexamate with HCl.
  • Therapeutic FunctionAntifibrinolytic
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