ChemicalBook Product Catalog Biochemical Engineering Natural Products Erinacine A Erinacin A

Erinacine A Erinacin A

Product NameErinacine A Erinacin A
CAS156101-08-5
MFC25H36O6
MW432.55
EINECS
MOL File156101-08-5.mol

Chemical Properties

Boiling point	610.8±55.0 °C(Predicted)
Density	1.24±0.1 g/cm3(Predicted)
solubility	Acetonitrile: Soluble Methanol: Soluble
form	Solid
pka	13.01±0.70(Predicted)
color	Light yellow to yellow

Usage And Synthesis

Uses

(+)-Erinacin A is a diterpenoid derivative isolated from the mushroom Hericium erinaceum. It can increase the catecholamine and nerve growth factor (NGF) content in the central nervous system of rats.

in vivo

(+)-Erinacin A (1, 5 and 10 mg/kg, i.p.; single dose) inhibits neuronal cell death in SAM rats with transient stroke and suppresses the expression of inflammatory cytokines in SAM brain tissues with transient stroke^[4]. (+)-Erinacin A (1, 2 and 5 mg/kg, i.p.; once a day for 5 days) significantly reduces tumor volume in DLD-1 xenograft mice^[5].

Animal Model:	DLD-1 xenograft mouse model^[5].
Dosage:	1, 2 and 5 mg/kg
Administration:	Intraperitoneal injection (i.p.) once a day for 5 days
Result:	Inhibited tumor volume by 60%, 32% and 26%.

Animal Model:	SAM rats with transient stroke^[4].
Dosage:	1, 5 and 10 mg/kg
Administration:	Intraperitoneal injection (i.p.) single dose
Result:	Induced NeuN immune response in the entire brain region of SAM rats, and increased the number of NeuN cells. Inhibited the activation of iNOS and p38/MAPK pathways and the expression of CHOP and nitrotyrosine proteins in rat brain tissue.

References

[1] HIROKAZU KAWAGISHI ∗ . Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum[J]. Tetrahedron Letters, 1994, 35 10: Pages 1569-1572. DOI: 10.1016/s0040-4039(00)76760-8
[2] CHIEN-CHANG LU . Inhibitory effect of Erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21[J]. Journal of Functional Foods, 2016, 21: Pages 474-484. DOI: 10.1016/j.jff.2015.12.031
[3] KAM-FAI LEE. Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease.[J]. Antioxidants, 2020. DOI: 10.3390/antiox9020137
[4] PEI-CHIEN HSU . Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury[J]. Life sciences, 2022, 306: Article 120833. DOI: 10.1016/j.lfs.2022.120833

Erinacine A Erinacin A Supplier

Erinacine A Erinacin A manufacturers

Related Product Information

Send Inquriy