Cycloheterophyllin exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA).
Cycloheterophyllin has an antioxidant effect and can effectively scavenge free radicals.
3. Cycloheterophyllin is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.
4. Cycloheterophyllin shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation, due to an inhibitory effect on cyclooxygenase.
Cycloheterophyllin is a flavonoid, that can be isolated from Artocarpus communis and A. heterophyllus. Cycloheterophyllin shows antiinflammatory activity[1].
ChEBI: Cycloheterophyllin is an extended flavonoid.
PKA | PKC | NADPH-oxidase | NF-kB | Caspase | MAPK
[1] Wei BL, et al. Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. J Agric Food Chem. 2005 May 18;53(10):3867-71. DOI:
10.1021/jf047873n
