2-Amino-thiazole-4-carboxylamide

5398-36-7

118452-02-1

General procedure for the synthesis of 2-aminothiazole-4-carboxylic acid from ethyl 2-aminothiazole-4-carboxylate: 3.0 g of ethyl 2-aminothiazole-4-carboxylate was dissolved in 100 mL of ammonia, and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, the reaction solution was concentrated to dryness and left to precipitate needle-like crystals. The crystals were collected by filtration and washed several times with cold water to remove impurities. Finally, the product was dried at room temperature to give 1.9 g of 2-aminothiazole-4-carboxamide in 76% yield with a melting point of 208-211 °C.