ChEBI: Florylpicoxamid is a carboxylic ester resulting from the formal condensation of the carboxy group of N-{[3-(acetyloxy)-4-methoxypyridin-2-yl]carbonyl}-L-alanine with the hydroxy group of (2S)-1,1-bis(4-fluorophenyl)propan-2-ol. It is a fungicide introduced by Dow AgroSciences for the control of a wide variety of pathogens such as Septoria spp, Powdery Mildews, Botrytis spp, and others in cereals, vines, fruits, nuts and vegetables. It has a role as an agrochemical and a fungicide. It is an acetate ester, an aromatic ether, a pyridinecarboxamide, a secondary carboxamide, a L-alanine derivative, a member of monofluorobenzenes and a carboxylic ester.
Florylpicoxamid is produced through a conventional small-molecule agrochemical process in which the picolinamide core is assembled first, then elaborated into the highly substituted bicyclic amide that defines the active ingredient. Commercial routes involve constructing the fluorinated picolinamide scaffold via halogenated pyridine intermediates, introducing the difluoromethyl and trifluoromethyl groups through controlled fluorination or coupling steps, and forming the bicyclic oxazepine ring system through intramolecular cyclisation of a pre-functionalised amide. The final stages involve purification, salt or crystalline form selection to ensure stability.
