Triazavirin

Product NameTriazavirin
CAS928659-17-0
MFC5H7N6NaO4S
MW270.2
EINECS690-013-3
MOL File928659-17-0.mol

Chemical Properties

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO: 125 mg/mL (436.76 mM)
form	A solid
color	Light yellow to yellow
InChI	InChI=1S/C5H4N6O3S.Na.H2O.H/c1-15-5-6-4-8-7-2(11(13)14)3(12)10(4)9-5;;;/h1H3,(H,6,8,9);;1H2;
InChIKey	HSYOIVJKWAPORA-UHFFFAOYSA-N
SMILES	O=C1C(=NN=C2NC(SC)=NN12)N(=O)=O.[NaH].O

Usage And Synthesis

Uses

Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza[1].

Biological Activity

Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid, which inhibits the synthesis of viral RNA and DNA and the replication of genomic fragments. It is active against influenza and many other viruses, and acts as an effective protective agent during influenza transmission.

in vitro

The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain < i> Sofiin ) by accumulation in the SKEV cell culture.

in vivo

The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed.

target

Nucleoside analogue; Influenza virus

References

[1] Kozhikhova KV, et al. Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drug Triazavirin. Pharm Dev Technol. 2018 Apr;23(4):334-342. DOI:10.1080/10837450.2016.1242624
[2] Loginova SIa, et al. Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture. Antibiot Khimioter. 2014;59(1-2):3-5. PMID:25051708
[3] Loginova SY, et al. Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice. Antibiot Khimioter. 2015;60(7-8):11-3. PMID:26863736

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