1A,1B-DIHOMO PROSTAGLANDIN E1

Prostaglandin E₁ (PGE₁) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.^1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE₁. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.³ In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE₁ was found to be much less active than PGE₁ itself.⁴

ChEBI: 1a,1b-dihomo-PGE1 is a prostanoid.

1. Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases J. Urol. 145(2),287-293(1991).
2. Hoshi, K. Approved indications of lipo-PGE₁ in Japan Adv. Drug Deliv. Rev. 20(2-3),171-176(1996).
3. Samel, N., and Maxey, K.M. Personal Communication ,(2003).
4. Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins Biochim. Biophys. Acta 187(3),285-292(1969).