Description
Prostaglandin E
1 (PGE
1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.
1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE
1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.
3 In
ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE
1 was found to be much less active than PGE
1 itself.
4
Definition
ChEBI: 1a,1b-dihomo-PGE1 is a prostanoid.
References
1. Virag, R., Shoukry, K., Floresco, J., et al.
Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases J. Urol. 145(2),287-293(1991).
2. Hoshi, K.
Approved indications of lipo-PGE1 in Japan Adv. Drug Deliv. Rev. 20(2-3),171-176(1996).
3. Samel, N., and Maxey, K.M.
Personal Communication ,(2003).
4. Kloeze, J.
Relationship between chemical structure and platelet-aggregation activity of prostaglandins Biochim. Biophys. Acta 187(3),285-292(1969).
