1a,1b-dihomo Prostaglandin E
2 (PGE
2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid .
1 1a,1b-dihomo PGE
2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid (AA; ).
2 This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
2
1. Tobias, L.D., Vane, F.M., and Paulsrud, J.R. The biosynthesis of 1a,1b-dihomo-PGE2 and 1a,1b-dihomo-PGF2a from 7,10,13,16-docosatetraenoic acid by an acetone-pentane powder of sheep vesicular gland microsomes Prostaglandins 10(3),443-468(1975).
2. Harkewicz, R., Fahy, E., Andreyev, A., et al. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells J. Biol. Chem. 282(5),2899-2910(2007).
