Description
1a,1b-dihomo Prostaglandin E
2 (PGE
2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid .
1 1a,1b-dihomo PGE
2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid (AA; ).
2 This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
2
Uses
1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
References
1. Tobias, L.D., Vane, F.M., and Paulsrud, J.R.
The biosynthesis of 1a,1b-dihomo-PGE2 and 1a,1b-dihomo-PGF2a from 7,10,13,16-docosatetraenoic acid by an acetone-pentane powder of sheep vesicular gland microsomes Prostaglandins 10(3),443-468(1975).
2. Harkewicz, R., Fahy, E., Andreyev, A., et al.
Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells J. Biol. Chem. 282(5),2899-2910(2007).
