2-Benzyloxybenzaldehyde

• 2-benzyloxy-2′-hydroxy-3′,4′,6′-trimethoxychalcone
• N²-(2-benzyloxy)benzylidenyl isonicotinic acid hydrazide
• 2-hydroxy-2′-methoxybenzophenone
• 2′-hydroxy-5,6,7-trimethoxyflavone

100-44-7

90-02-8

5896-17-3

(Preparation of 2-benzyloxybenzaldehyde) 185 g of N,N-dimethylformamide (DMF) and 82.8 g (0.6 mol) of anhydrous potassium carbonate were added to a three-necked flask, and 61 g (0.5 mol) of salicylaldehyde was added slowly dropwise under stirring. Subsequently, the reaction system was warmed up to 50 °C, and 75.9 g (0.6 mol) of benzyl chloride was slowly added dropwise at this temperature for a controlled dropwise time of 1 hour. After the dropwise addition was completed, the reaction mixture was warmed up to 70 °C and the reaction was continued with stirring for 2 hours. Upon completion of the reaction, the mixture was transferred to a partition funnel and washed sequentially with 185 g of toluene and 330 g of water. The organic phases were combined and the solvent was removed by distillation under reduced pressure (internal temperature 90 °C, pressure 10 mmHg) to give 104.5 g of the brown liquid product 2-benzyloxybenzaldehyde, which was analyzed to have a purity of 97.9% and a yield of 96.5%.