| Result: | Inhibited TNBS-induced body weight reduction, colon shortening, macroscopic score, and myeloperoxidase activity.
Inhibited the expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
Ameliorated changes of TNBS-treated mouse colons which showed increased neutrophils, massive bowel edema, dense infiltration of the superficial layers of the mucosa, and epithelial cell disruption by large ulcerations.
Inhibited the expression of TLR4, COX-2, and iNOS and the phosphorylation of IRAK1, IKK-β and p65, although it reversed IRAK-1 expression.
|
