Niclosamide Monohydrate can be used as oral therapeutics.
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate is used as an anthelmintic drug (Cestodes).
Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].
| Animal Model: | Nu+/Nu+ mice injected with NCI-H295R cells[3] |
| Dosage: | 100 mg/kg, 200 mg/kg |
| Administration: | Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks |
| Result: | Showed a 60%-80% inhibition in tumor growth, as compared to the control group. |
STAT3: 0.25 μM (IC50, in HeLa cells)
