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STAUROSPORINE

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STAUROSPORINE Basic information
STAUROSPORINE Chemical Properties
  • Melting point:270°C
  • alpha D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
  • Boiling point:677.5±55.0 °C(Predicted)
  • Density 1.56±0.1 g/cm3(Predicted)
  • RTECS KD5084000
  • storage temp. 2-8°C
  • solubility DMSO: soluble
  • form White to pale yellow solid
  • pka14.25±0.70(Predicted)
  • Water Solubility Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
  • BRN 1060573
  • InChIKeyHKSZLNNOFSGOKW-WIFUGMKFSA-N
  • CAS DataBase Reference62996-74-1
Safety Information
MSDS
STAUROSPORINE Usage And Synthesis
  • Chemical PropertiesLight Yellow Solid
  • OccurrenceA complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.
  • UsesA protein Kinase C inhibitor that induces apoptosis in many cell types
  • UsesStaurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
  • Biological ActivityBroad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
STAUROSPORINE(62996-74-1)Related Product Information
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