Basic information Bromoquinoline Application and synthesis method Uses Safety Related Supplier
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3-Bromoquinoline

Basic information Bromoquinoline Application and synthesis method Uses Safety Related Supplier
3-Bromoquinoline Basic information
3-Bromoquinoline Chemical Properties
  • Melting point:13-15 °C (lit.)
  • Boiling point:274-276 °C (lit.)
  • Density 1.533 g/mL at 25 °C (lit.)
  • refractive index n20/D 1.664(lit.)
  • Flash point:>230 °F
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • pka2.69(at 25℃)
  • form Liquid
  • color Clear colorless to yellow
  • BRN 112939
  • InChIKeyZGIKWINFUGEQEO-UHFFFAOYSA-N
  • CAS DataBase Reference5332-24-1(CAS DataBase Reference)
  • NIST Chemistry ReferenceQuinoline, 3-bromo-(5332-24-1)
  • EPA Substance Registry SystemQuinoline, 3-bromo- (5332-24-1)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36-37/39
  • RIDADR UN2810
  • WGK Germany 3
  • TSCA Yes
  • HS Code 29334900
MSDS
3-Bromoquinoline Usage And Synthesis
  • BromoquinolineThere are seven position isomers with the main properties are as follows:
    Name
    Melting point(℃)
    Boiling point(℃)
    Solubility
    2-bromoquinoline
    48~49
    It is soluble in diethyl ether, chloroform and benzene
    3-bromoquinoline
    12~15
    274~276, 95(66.66Pa)
    4-bromoquinoline
    29~30
    270(decomposition)
    Easily soluble in dilute acid
    5-bromoquinoline
    52 (needle crystal)
    280
    6-bromoquinoline
    24
    278
    7-bromoquinoline
    52 (needle crystal)
    290
    8-bromoquinoline
    80
    165~166
    (2399.79Pa)
  • Application and synthesis method3-Bromoquinoline can have action with mixed acid to generate 3-bromo-5-nitroquinoline, followed by heating with potassium permanganate to be oxidized to 5-bromo-2, 3-pyridine dicarboxylic acid.
    6-bromo-quinoline can be heated together nitric acid to generate 6-bromo-8-nitro-quinoline, followed by reaction with potassium permanganate to be oxidized into 2, 3-pyridinedicarboxylic acid.
    2-bromo-quinoline can be manufactured through the reaction between 2-hydroxyquinoline and phosphorus pentabromide
    3-bromo-quinoline can be obtained through heating the quinoline perbromide at 180 ° C.
    4-bromoquinoline can be obtained through either the heating reaction between 4-hydroxyquinoline and phosphorus pentabromide or by the diazotization reaction of 4-aminoquinoline.
    5-bromo-quinoline can be obtained from the heating reaction between m-bromo aniline, glycerol, m-bromonitrobenzene and concentrated sulfuric acid, or through the diazotization reaction of 5-amino-quinoline.
    6-bromo-quinoline can be obtained through the heating reaction between p-bromoaniline, glycerol, concentrated sulfuric acid and p-bromo-nitrobenzene.
    7-bromoquinoline can be obtained through the diazotization of 7-aminoquinoline.
    8-bromo-quinoline can be obtained through the heating of o-bromo aniline, glycerol, concentrated sulfuric acid and o-bromo-nitrobenzene in the heating system.
    Purposes: as organic synthesis reagents.
  • UsesFor pharmaceuticals
    Medicine, pesticide intermediates
  • Chemical Propertiescolorless to light yellow liquid
  • Synthesis Reference(s)The Journal of Organic Chemistry, 27, p. 1318, 1962 DOI: 10.1021/jo01051a047
3-Bromoquinoline Preparation Products And Raw materials
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