1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA

light brown fine crystalline powder

U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2].

[1] Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. DOI:10.3181/00379727-133-34571
[2] Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. DOI:10.1016/0006-2952(80)90345-7