1-Hydroxypiperidine

110-89-4

4801-58-5

General procedure for the synthesis of N-hydroxypiperidine from hexahydropyridine: hexahydropyridine (5 mmol) and ChPS (5.5 mmol) were added to a round-bottomed flask under nitrogen protection, and the reaction was stirred for 1 hr at 60 °C. After completion of the reaction, the mixture was dissolved in water (5 mL) and the product was extracted with dichloromethane or ethyl acetate (5 mL each time, 3 times). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the target product N-hydroxypiperidine.