3-Bromo-4-fluorobenzaldehyde

white to light yellow low melting solid

3-Bromo-4-fluorobenzaldehyde was used in the synthesis of 4-fluoro-3-phenoxybenzoic acid-glycine. It was also used in the synthesis of Schiff bases of 4-nitroaniline/ 2,4-dinitroaniline/3,4-dichloroaniline/4-methoxy-3-nitro aniline via ultrasound irradiation method.

3-Bromo-4-fluorobenzaldehyde can be used for pest control.

A synthetic method of 3-bromo-4-fluorobenzaldehyde comprises the following steps: (1) dissolving 4-fluorobenzaldehyde in dichloromethane to obtain a solution A; (2) dissolving sodium bromide in pure water and adding 35% hydrochloric acid while stirring to obtain a solution B; (3) mixing the solution A and the solution B, starting ultrasonic waves, and dropwise adding a sodium hypochlorite aqueous solution under stirring; (4) after the dripping is finished, carrying out ultrasonic treatment, keeping the temperature under stirring, and then standing; (5) phase separation, washing dichloromethane phase to neutrality, drying and desolventizing; (6) obtaining a crude product, and carrying out bulk melting crystallization at 31 ℃ to obtain a pure product.

[1] Patent: WO2010/86877, 2010, A2. Location in patent: Page/Page column 11-12
[2] Patent: US5225607, 1993, A
[3] Patent: US4791139, 1988, A
[4] Patent: US4792563, 1988, A
[5] Patent: EP240121, 1991, B1