6-Bromoveratraldehyde

120-14-9

5392-10-9

(1) Add 529 g of bromine dropwise to 500 g of 3,4-dimethoxybenzaldehyde dissolved in 2.5 L of methanol at room temperature (cooled if necessary) within 1 hour and stir the reaction mixture at the same temperature for 3 hours. Subsequently, 2.5 L of water was slowly added dropwise to the reaction solution to induce precipitation of crystals. A 20% aqueous sodium hydroxide solution was added to the crystal suspension at room temperature and the pH was adjusted to about 9-10, followed by cooling. The precipitated crystals were collected by filtration, washed with water and dried at 50 °C for 12 h. 718.78 g of 6-bromo-3,4-dimethoxybenzaldehyde was finally obtained (yield: 98%).