SBI-810 hydrochloride is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 hydrochloride modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT). SBI-810 hydrochloride fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12[1][2].
[1] Lawrence Barak, et al. Compositions for and methods of treating and/or preventing pain. WO2022241186A1. 2022 November 17.
[2] Center M N A, et al. Summer Undergraduate Research Expo[J]. 2014.
