Reboxetine can be used in biological study of the involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test.
Antidepressant (selective noradrenaline reuptake inhibitor).
ChEBI: Reboxetine is an aromatic ether.
Edronax (Pharmacia & Upjohn).
Potent and selective inhibitor of noradrenalin uptake (K i values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α -adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active, clinically used antidepressant.
