基本属性 生物活性体外研究体内研究 MSDS 用途与合成方法 米帕林盐酸盐 价格(试剂级) 供应商 供应信息 相关产品
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米帕林盐酸盐

基本属性 生物活性体外研究体内研究 MSDS 用途与合成方法 米帕林盐酸盐 价格(试剂级) 供应商 供应信息 相关产品
米帕林盐酸盐
  • 中文名称:米帕林盐酸盐
  • 英文名称:Mepacrine hydrochloride
  • CAS号:6151-30-0
  • 分子式:C23H36Cl3N3O3
  • 分子量:508.91
  • EINECS号:
  • Mol文件:6151-30-0.mol
  • 米帕林盐酸盐
米帕林盐酸盐 性质
米帕林盐酸盐 用途与合成方法
  • 生物活性Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) 是一种抗疟剂 (antimalarial),在体内外均具有抗肿瘤作用。Quinacrine hydrochloride hydrate 抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡 (apoptosis)。
  • 体外研究

    Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
    Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
    Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .

    Cell Viability Assay

    Cell Line: SGC-7901 cells
    Concentration: 0, 5, 10, 15, and 20 μM
    Incubation Time: 24 hours
    Result: Cell viability was inhibited in a dose-dependent manner, and the mean IC 50 value is 16.18 μM.

    Apoptosis Analysis

    Cell Line: SGC-7901 cells
    Concentration: 7.5 and 15 μM
    Incubation Time: 24 hours
    Result: The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.

    Western Blot Analysis

    Cell Line: SGC-7901 cells
    Concentration: 15 μM
    Incubation Time: 24 hours
    Result: The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
    The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
    The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
  • 体内研究

    Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.

    Animal Model: Female SCID mice with acute myeloid leukemia (AML)-PS model
    Dosage: 100 mg/kg
    Administration: Administered by oral gavage (po); three times a week for two consecutive weeks
    Result: In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
    The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
安全信息
MSDS信息
  • 语言:English提供商:ACROS
  • 更新日期2021-12-30
  • 产品编号S5435
  • 产品名称米帕林盐酸盐
  • CAS编号6151-30-0
  • 包装25mg
  • 价格794.67
  •  
  • 更新日期2021-06-02
  • 产品编号S5435
  • 产品名称米帕林盐酸盐
  • CAS编号6151-30-0
  • 包装25mg
  • 价格794.67
米帕林盐酸盐供应商更多
  • 公司名称:斯百全化学(上海)有限公司
  • 联系电话:18616765336
  • 产品介绍: 英文名称:Quinacrine Hydrochloride, Dihydrate
    CAS:6151-30-0
    包装信息:25KGBL 备注:Q1013
  •  
  • 公司名称:杭州杰恒化工有限公司
  • 联系电话:0571-87396432-
  • 产品介绍: 英文名称:Quinacrine,Atabrine Mepacnine
    CAS:6151-30-0
  •  
  • 公司名称:上海寰川实业有限公司
  • 联系电话:021-61478794
  • 产品介绍: 英文名称:Mepacrine hydrochloride
    CAS:6151-30-0
    纯度:95% 包装信息:25g 100g
  •  
  • 公司名称:池州凯隆进出口贸易有限公司
  • 联系电话:Please Email
  • 产品介绍: 中文名称:米帕林盐酸盐; 奎纳克林盐酸盐; N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二盐酸盐二水合物
    英文名称:1,4-PentanediaMine,N4-(6-chloro-2-Methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride, hydrate(1:2:2)
    CAS:6151-30-0
    纯度:Min 98% 包装信息:suitable for international transportation
  •  
  • 公司名称:AN PharmaTech Co Ltd
  • 联系电话:86(21)68097365
  • 产品介绍: CAS:6151-30-0
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