ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Cyclodextrin > β-Cyclodextrin, sulfobutyl ethers, sodium salts
β-Cyclodextrin, sulfobutyl ethers, sodium salts
β-Cyclodextrin, sulfobutyl ethers, sodium salts Chemical Properties
- solubility Soluble in water. Insoluble in acetone, methanol, chloroform.
- form Solid powder
- color White to off white
- HS Code 2940006000
β-Cyclodextrin, sulfobutyl ethers, sodium salts Usage And Synthesis
- Chemical Propertiesβ-Cyclodextrin, sulfobutyl ethers, sodium salts is White powder.
- Chemical Propertiesβ-Cyclodextrin, sulfobutyl ethers, sodium salts is a cyclic oligosaccharide containing seven D-(t)- glucopyranose units attached by α(1→4) glucoside bonds. Sulfobutylether b-cyclodextrin is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into b-cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties. Sulfobutylether b-cyclodextrin occurs as a white amorphous powder.
- Usesβ-Cyclodextrin, sulfobutyl ethers, sodium salts with sulfobutyl ether groups and sodium ions substituted along the length of the molecule. β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin, sulfobutyl ethers, sodium salts is commonly used to produce HPLC columns allowing chiral enantiomers separation.
- UsesSBE- β –CD is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.
- Production MethodsSulfobutylether β-cyclodextrin is prepared by alkylation of bcyclodextrin using 1,4-butane sultone under basic conditions. The degree of substitution in b-cyclodextrin is controlled by the stoichiometric ratio of β-cyclodextrin to sultone used in the process.
- Pharmaceutical ApplicationsCyclodextrins are crystalline, nonhygroscopic, cyclic oligosaccharides
derived from starch (see Cyclodextrins). Sulfobutylether bcyclodextrin
is an amorphous, anionic substituted b-cyclodextrin
derivative; other substituted cyclodextrin derivatives
are also available.
Sulfobutylether b-cyclodextrin can form noncovalent complexes with many types of compounds including small organic molecules, peptides, and proteins. It can also enhance their solubility and stability in water. The first application of sulfobutylether bcyclodextrin was in injectable preparations; it can also be used in oral solid and liquid dosage forms, and ophthalmic, inhalation, and intranasal formulations. Sulfobutylether bcyclodextrin can function as an osmotic agent and/or a solubilizer for controlled-release delivery, and has antimicrobial preservative properties when present at sufficient concentrations.
The amount of sulfobutylether β-cyclodextrin that may be used is dependent on the purpose for inclusion in the formulation, the route of administration, and the ability of the cyclodextrin to complex with the drug being delivered. The minimum amount required for solubilization is, in general, a cyclodextrin/drug molar ratio of approximately 1–5 (the exact ratio being experimentally determined from complexation data). The maximum use in a formulation may be limited by physicochemical constraints such as viscosity (e.g. syringeable concentrations may be considered up to 50% w/v), tonicity, or the total weight and size of solid dosage forms (e.g. less than a gram in an individual tablet). It may also be limited by pharmacokinetic/pharmacodynamic (PK/PD) considerations. As dilution of a cyclodextrin formulation leads to an increase in the amount of uncomplexed drug, formulations that are not diluted upon administration, such as ophthalmic formulations, are sensitive to cyclodextrin concentration. In formulations such as these, cyclodextrin concentrations greater than the minimum required for solubilization can reduce the availability of uncomplexed drug and thereby affect PK/PD expectations by producing effects such as slower onset, lower Cmax, and bioavailability.
- SafetySulfobutylether b-cyclodextrin is derived from b-cyclodextrin,
which is nephrotoxic when administered parenterally.
However, studies have shown that sulfobutylether bcyclodextrin
is well tolerated at high doses, when administered via
intravenous bolus injections, orally, and by inhalation. Up to
9 g/day may be administered by IV infusion in a licensed
voriconazole formulation. The safety following high doses of
sulfobutylether β-cyclodextrin intravenous administration in
humans is continually being investigated.
Sulfobutylether β-cyclodextrin has been subjected to an extensive battery of in vitro and in vivo genotoxicity and pharmacological evaluations. No genotoxic or mutagenic changes were observed with sulfobutylether β-cyclodextrin administration. Sulfobutylether β-cyclodextrin is biocompatible and exhibits no pharmacological activity. It is rapidly eliminated unmetabolized when administered intravenously.
- storageSulfobutylether b-cyclodextrin is stable in the solid state and should be protected from high humidity. It should be stored in a tightly sealed container in a cool, dry place.
It will reversibly take up moisture without any effect on the appearance of the material at humidities up to 60% RH. Equilibration at RH values above 60% will result in deliquescence. Once in this state, the material can be dried, but will give a glasslike product. This water absorption behavior is typical of amorphous hygroscopic materials.
Sulfobutylether b-cyclodextrin is stable in aqueous solutions at values above about pH 1. It can degrade in highly acidic (pH < 1) solutions, particularly at elevated temperatures, producing the ring-opened form, followed by hydrolysis of the a(1-4) glucoside bonds.
Sulfobutylether b-cyclodextrin solutions may be autoclaved.
- IncompatibilitiesThe preservative activity of benzalkonium chloride is reduced in the presence of sulfobutylether b-cyclodextrin.
- Regulatory StatusSulfobutylether β-cyclodextrin is included in IV and IM injectable products currently approved and marketed in the USA, Europe, and Japan. It is included in the FDA Inactive Ingredients Database for IM and IV use. Its use by other routes, including SC, oral, inhalation, nasal and ophthalmic, is being evaluated in clinical studies.
- Posaconazole N/A 2-hydroxypropyl-α-cyclodextrin ALPHA-CYCLODEXTRIN SULFATED SODIUM SA& 6-O-ALPHA-D-GLUCOSYL-BETA-CYCLODEXTRIN piroxicam-beta-cyclodextrin CARBOXYMETHYL BETA-CYCLODEXTRIN HYDROXYETHYL BETA-CYCLODEXTRIN Hydroxypropyl-beta-cyclodextrin 2-Hydroxypropyl-β-cyclodextrin TRIMETHYL-BETA-CYCLODEXTRIN Cyclooctapentylose 3-FLUORO-4-NITROTOLUENE BETA-CYCLODEXTRIN beta-Cyclodextrin methyl ethers Heptakis-(6-Mercapto-6-deoxy)-beta-Cyclodextrin 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN Cyclohexapentylose
β-Cyclodextrin, sulfobutyl ethers, sodium saltsSupplierMore
- Company Name:Hubei kangmingde Pharmaceutical Chemical Co., Ltd Gold
- Tel:15008015258 027-89771658-
- Company Name:Chembest Research Laboratories Limited Gold
- Company Name:Hefei QiChang Biological Technology Co., Ltd. Gold
- Company Name:Tocopharm Co., Ltd. Gold
- Tel:13776836200 021-69895597-
- Company Name:Shandong Zhiyuan Biotechnology Co., Ltd. Gold