硝呋替莫
硝呋替莫 性质
| 熔点 | 177-183°C |
|---|---|
| 沸点 | 550.3±50.0 °C(Predicted) |
| 密度 | 1.4716 (rough estimate) |
| 折射率 | 1.6390 (estimate) |
| 储存条件 | room temp |
| 溶解度 | 在DMSO中的溶解度≥13mg/mL |
| 酸度系数(pKa) | -1.01±0.40(Predicted) |
| 形态 | 粉末 |
| 颜色 | 黄色至橙色粘性至蜡状 |
| 水溶解性 | 33g/L(temperature not stated) |
| BCS Class | 3 |
| InChI | 1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+ |
| InChIKey | ARFHIAQFJWUCFH-IZZDOVSWSA-N |
| SMILES | CC1CS(=O)(=O)CCN1\N=C\c2ccc(o2)[N+]([O-])=O |
硝呋替莫 用途与合成方法
Trypanosoma cruzi
Lactate dehydrogenase (LDH)
Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH). To differentiate if this effect is a result of a reduced LDH activity or a shift in pyruvate metabolism due to activation of PDH, the enzyme activity of LDH is determined after 4 h treatment with 50 µg/mL Nifurtimox. Compared to the untreated control, the LDH activity is significantly reduced for LA-N-1 (P=0.005), IMR-32 (P=0.009), LS (P=0.0035) and SK-N-SH (P=0.0065). Nifurtimox reduces cell viability and induces cell cycle arrest and apoptosis in neuroblastoma cells. To characterize the cytotoxic impacts of Nifurtimox on neuroblastoma, 4 cell lines are subjected to several experiments. Cell viability is reduced for all 4 neuroblastoma cell lines after 24 h incubation with 50 µg/mL to an average of 66%, 63%, 62% and 75% (LA-N-1, IMR-32 LS and SK-N-SH, respectively). The reduction is significant compared to the untreated control (P<0.01) and the vehicle control with DMSO (P<0.05) for all cell lines.
硝呋替莫 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-W040073R | 硝呋替莫 | 23256-30-6 | 5 mg | 1092 |
| 2026-06-05 | HY-W040073R | 硝呋替莫 | 23256-30-6 | 10 mg | 1750 |
