1-Boc-3-methyl-piperidin-4-one

34737-89-8

24424-99-5

181269-69-2

The general procedure for the synthesis of N-Boc-3-methyl-piperidin-4-one (product 27B) from 1-benzyl-3-methyl-piperidin-4-one (compound 28, 15.0 g, 0.0738 mol) and di-tert-butyl dicarbonate (17.7 g, 0.0812 mol) was as follows: compound 28 and di-tert-butyl dicarbonate were dissolved in ethyl acetate (EtOAc , 400 mL). Palladium hydroxide catalyst (4 g) was added to the solution and the mixture was placed in a Paar oscillator and the reaction was oscillated at 40 psi hydrogen pressure for 24 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the diatomaceous earth was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to give the colorless oily product 27B (15.73 g, 0.0738 mol, 100% yield). Mass spectrometry analysis (ESI+, M-tBOC): m/z 114.