ChemicalBook Product Catalog Biochemical Engineering Polypeptide Thr-Arg-Ser-Ala-Trp

Thr-Arg-Ser-Ala-Trp

Product NameThr-Arg-Ser-Ala-Trp
CAS138949-73-2
MFC27H41N9O8
MW619.67
EINECS
MOL File138949-73-2.mol

Chemical Properties

storage temp.	-15°C
form	Solid
Sequence	Thr-Arg-Ser-Ala-Trp

Usage And Synthesis

Uses

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

in vivo

Osteostatin (80 or 120 μg/kg,; after the onset of disease s.c. every day for 13 days) decreases the severity of arthritis as well as cartilage and bone degradation^[4].

Animal Model:	Collagen-induced arthritis in male DBA/1 mice^[4]
Dosage:	80 or 120 μg/kg
Administration:	After the onset of disease s.c. every day for 13 days
Result:	Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.

References

[1] Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. DOI:10.1210/endo-129-6-3424
[2] Ibáez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[3] Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. DOI:10.1016/j.actbio.2009.08.033
[4] Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845. DOI:10.3390/ijms20163845

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