ChemicalBook CAS DataBase List Thr-Arg-Ser-Ala-Trp

Thr-Arg-Ser-Ala-Trp

Product NameThr-Arg-Ser-Ala-Trp
CAS138949-73-2
CBNumberCB3689855
MFC27H41N9O8
MW619.67
MDL NumberMFCD00133747
MOL File138949-73-2.mol

Chemical Properties

storage temp.	-15°C
form	Solid
Sequence	Thr-Arg-Ser-Ala-Trp

Thr-Arg-Ser-Ala-Trp Price

Product number	Packaging	Price	Product description	Buy
Biosynth VAC-00776	5mg	$154.25	Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)	Buy
Biosynth VAC-00776	10mg	$257.1	Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)	Buy
Biosynth VAC-00776	25mg	$514.5	Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)	Buy
Biosynth FO110332	10mg	$900	Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt	Buy
Biosynth FO110332	5mg	$900	Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt	Buy

Thr-Arg-Ser-Ala-Trp Chemical Properties,Usage,Production

Uses

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

in vivo

Osteostatin (80 or 120 μg/kg,; after the onset of disease s.c. every day for 13 days) decreases the severity of arthritis as well as cartilage and bone degradation^[4].

Animal Model:	Collagen-induced arthritis in male DBA/1 mice^[4]
Dosage:	80 or 120 μg/kg
Administration:	After the onset of disease s.c. every day for 13 days
Result:	Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.

References

[1] Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. DOI:10.1210/endo-129-6-3424
[2] Ibáez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[3] Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. DOI:10.1016/j.actbio.2009.08.033
[4] Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845. DOI:10.3390/ijms20163845

Preparation Products And Raw materials

Thr-Arg-Ser-Ala-Trp Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28149	68
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4727	58
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19087	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58

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