Ferritin

Description

Ferritin is the cellular storage protein for iron. Most of the iron stored in the body is bound to ferritin. Ferritin is found in the liver, spleen, skeletal muscles, and bone marrow. A small amount of ferritin is found in blood. Ferritins are also able to store a significant quantity of iron within a hollow core, and act as storage systems for iron within cells. The primary role of ferritin is to protect cells from the damage caused by the Fenton reaction: free Fe(II) in oxidizing conditions produces harmful reactive oxygen species that can damage the cellular machinery.
The serum ferritin concentration normally correlates well with total-body iron stores, making its measurement important in the diagnosis of disorders of iron metabolism. Ferritin level blood test can be used to test ferritin levels. Low ferritin levels could be caused by iron deficiency, anemia, excessive menstrual bleeding, stomach conditions that affect intestinal absorption, and internal bleeding. High ferritin levels indicate certain conditions including hemochromatosis, rheumatoid arthritis, liver disease, hyperthyroidism, adult Still’s disease, type 2 diabetes, leukemia, Hodgkin’s lymphoma, iron poisoning, and frequent blood transfusions.

Uses

Ferritin is an iron-containing protein with electron-dense characteristics, enabling the ultrastructural identification and localization of antigens and antibodies within tissue cells. It holds broad promise for medical and biological research. Clinically, serum ferritin is commonly used to evaluate iron status and diagnose anemia and iron overload. Furthermore, ferritin testing is applied to the research and auxiliary diagnosis of diseases such as adult Still's disease, hemophagocytic syndrome, sideroblastic anemia, myelodysplastic syndrome classification, Parkinson's disease, coronary heart disease, and breast cancer. It can also serve as a prognostic indicator for patients undergoing allogeneic hematopoietic stem cell transplantation.

Definition

An iron–protein complex in which iron is stored in the intestinal mucosa, spleen, and liver. It regulates iron transport from the intestinal lumen to plasma in circulating blood.

Hazard

Questionable carcinogen; neoplastigen; mutagen.

References

[1] http://www.webmd.com
[2] http://www.healthline.com